Iran-backed Houthi forces struck the US-owned and operated container ship M/V Gibraltar Eagle with an anti-ship ballistic missile on Monday.
US Central Command announcing the attack said there were no reports of injuries or significant damage.
The Iran-backed Houthis who control most of Yemen's Red Sea coast have been attacking commercial ships in the area they say are linked to Israel or bound for Israeli ports. The attacks began in mid-November after Iran’s Supreme Leader Ali Khamenei called for a blockade of Israel.
US and British forces responded last week by carrying out dozens of air and sea strikes on Houthi targets in Yemen.
Earlier in the day British Maritime Security firm Ambrey said that a Marshall Islands-flagged, US-owned bulk carrier was reportedly struck by a missile while transiting near Yemen's port of Aden.
The United Kingdom Maritime Trade Operations (UKMTO) agency said that a vessel was hit from above by a missile 95 nautical miles southeast of Aden, without identifying the vessel.
Ambrey said three missiles were reportedly launched by the Houthis, with two not reaching the sea and the third striking the bulk carrier.
Ambrey added that the impact reportedly caused a fire in a hold, but that the bulker remained seaworthy with no injuries on board.
Later on Monday an explosion was heard near Yemen's Hodeidah airport, residents reported. Hodeidah is some distance from Aden, however, and it was not immediately clear what had caused the blast.
The US military said on Sunday a US fighter jet shot down an anti-ship cruise missile that the Houthis fired towards the USS Laboon in the southern Red Sea.